Thiol derivative, a competitive hypoxanthine antagonist, has an immunosuppressive and cytostatic effect. It is used for prevention of rejection reaction in kidney transplantation, treatment of rheumatoid arthritis, chronic active hepatitis, SLE, dermatomyositis, periarteritis nodosa, acquired hemolytic anemia, gangrenous pyoderma, psoriasis, Crohn's disease, ulcerative colitis and myopathy.
Imuran
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Imuran Product Description
Drug Uses
Imuran is an immunosuppressive agent used for the suppression of immune responses in the treatment of autoimmune diseases or after organ transplantation. Imuran tablets can be used alone, or as a part of combined immunomodulatory therapy.
As an immunosuppressive antimetabolite, Imuran is approved as:
- Prevention of rejection of transplanted organs and improved survival after organ transplantation (including for medical management of renal, cardiac and hepatic transplant recipients).
- Management of active, severe, inflammatory and chronic autoimmune diseases of joints, skin, skeletal muscles, blood cells, arteries, liver and other organs and body systems.
Imuran maintenance dose to prevent transplant rejection ranges from 1mg to 4mg (once a day). The maintenance daily doses of Imuran for patients with autoimmune diseases vary from 1mg to 3mg (as a single or two divided doses).
Missed dose
If you take Imuran several times a day and skip a regular dose, take it as soon as you remember. Do not double Imuran dose and do not take extra immunosuppressive drugs to make up the missed dose.
More Information
To prevent transplant rejection, Imuran can be used together with other immunosuppressive agents. For symptomatic treatment of autoimmune diseases, Imuran can be used together with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs).
Storage
Imuran tablets should be protected from direct sunlight and stored in a dry place, at room temperature not exceeding 30°C.
Imuran Safety Information
Warnings
Drugs suppressing immune responses (such as, Imuran) may increase the risk of developing malignancies. Patients with high risk of malignancies should be prescribed with Imuran only if the benefits of immunosuppressive therapy outweigh the potential risks.
Disclaimer
Data about immunosuppressive therapy represented in this Imuran review is intended only for general information. This information in no case does not constitute an offer of a substitute for the immunologist’s professional medical advice or diagnosis of immune diseases. The online pharmacy shall not be held responsible for any damages resulting from the use of information about transplantation, autoimmune diseases and Imuran.
Imuran Side Effects
Imuran adverse reactions are reversible and disappear when decreasing the dose or duration of immunosuppressive therapy. The most severe adverse reactions of Imuran are hematologic and gastrointestinal disorders, such as leucopenia, infection, anemia, nausea, vomiting, hepatic toxicity, diarrhea, fever, malaise, vasculitis or muscle pain. Less often, Imuran may cause skin rashes, hair loss, fever, joint pain, steatorrhea, infections (e.g. viral, fungal and bacterial) or exanthem.
Prograf The active ingredient of the drug (Tacrolimus) binds to cytosolic protein (FKBP12), responsible for the intracellular accumulation of the drug. Designed for the prevention and treatment of allograft liver, kidneys and heart rejection reactions, including those resistant to standard immunosuppressive therapy regimes.
Geodon - antipsychotic medicine (neuroleptic). It is taken at treatment of schizophrenia and similar mental disorders (treatment and prevention of aggravations), stopping of psychomotor excitement at patients with schizophrenia.
An antidepressant from the group of selective inhibitors of serotonin reverse capture. It has thymoanaleptic and stimulating effect. Improves the mood, reduces tension, anxiety and fear, eliminates dysphoria. Doesn’t cause sedation. When taken in high therapeutic doses, it virtually doesn’t effect the function of cardiovascular and other systems.
It is a nonsteroidal anti-inflammatory agent that effectively inhibits the synthesis of prostaglandins, has antipyretic, anti-inflammatory and analgesic effects. In addition, it reversibly inhibits collagen-induced platelet aggregation. In oral administration, the drug is partly absorbed in the abdomen and then completely in the intestine. After metabolism in the liver (hydroxylation, carboxylation) pharmacologically inactive metabolites are completely excreted in the urine. In oral administration, the maximum concentration in blood plasma is achieved in 1-2 hours.
Cipro - the antimicrobic broad-spectrum agent derivative of fluroquinolone, suppresses bacterial DNA gyrase, breaks DNA synthesis, growth and division of bacteria; causes prominent morphological changes and fast death of a bacterial cell. It effects bactericidal at gram-negative organisms during a dormant period and deletion, on gram-positive microorganisms - only during deletion. During taking Cipro there is no parallel development of resistance to other antibiotics, which do not belong to group of inhibitors of a gyrase that does it highly effective in relation to bacteria which can be steady, for example to aminoglycosides, penicillin, cephalosporins, tetracyclines and many other antibiotics.
Eriacta is a potent and safe equivalent of Viagra, represented in the pharmaceutical niche by Ranbaxy Laboratories Limited. The consumption of the potency regulator named Eriacta eliminates erectile malady and permits one to conduct a rich sexual life.
Silagra tablets do a highly effective job of relaxing the musculature in the phallus. The drug increases the movement of blood in caverns of the erectile tissue by vasodilatory activity. It belongs to the category of medicines distributed as PDE5 blockers. Similarly to Viagra, these pills contain sildenafil citrate – a substance that mainly finds use as a cure for erectile disorders. Silagra mainly interacts with the circulatory function and requires an adequate sexual stimulation to set in action. Its effect can be felt in 30-40 minutes, resulting in about 4 hours of strong erection.
Levitra - the main component - the active agent Vardenafil which promotes strengthening of blood circulation in generative organs of men. It allows to reach a high level erection at sexual stimulation, and also to increase sensitivity of head of a penis and to make sexual intercourse longer and more pleasant. The main feature of a drug Levitra - quickness of effect, duration of impact on an organism up to 12 hours and a very small number of side effects.
Blocks the final stage of HCl secretion, reducing basal and stimulated secretion, regardless of the nature of the stimulus. Prescribed for gastric ulcer and duodenal ulcer in acute phase, erosive-ulcerative esophagitis, reflux esophagitis, Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract; eradication of Helicobacter pylori within a combination therapy, non-ulcer dyspepsia.
Aciphex - the medicine, normalizing acidity of a stomach, inhibitor of a proton pomp. It is prescribed at gastroduodenal ulcer in the exacerbation phase, gastroesophageal reflux disease; states which are characterized by pathological hyper secretion including Zollinger-Ellison syndrome. In combination with bactericide - Helicobacter pylori eradication at patients with gastric ulcer or chronic gastritis; treatment and prevention of recurrence of an ulcer at patients with gastric ulcer related to Helicobacter pylori.
Sinemet - a combined remedy based on Levodopum + Carbidopum. In the treatment of Parkinson's syndrome and disease, Sinemet proved to be one of the most effective drug. The reviews are mostly positive, because it allows to reduce "inhibition" in patients who have been treated with other medications. For each patient, the dosage is selected individually, together with the frequency of admission.
Hydrea - antineoplastic medicine, antimetabolite, slows down DNA synthesis. It is used for treatment of acute and chronic myelogenous leukemia, osteomyelofibrosis, erythremia, essential thrombocythaemia, thrombocytosis associated with myeloproliferative syndrome, lymphogranulomatosis, melanoma, ovarian cancer, horionepitelioma of uterus, tumor of the head and the neck, tumor of brain, an acute lymphoblastic leukosis at children, a colon cancer, a prostate cancer, cancer of a lung, cancer of a neck of uterus (for increase in efficiency of radiation therapy).
Dramamine is an antihistamine drug that reduces the effect of the natural chemical histamine in the body. Dramamine is used to treat or prevent the occurrence of nausea, vomiting, and dizziness associated with motion sickness.
Vasotec- an antihypertensive drug based on the action of the active ingredient Enalapril, whose mechanism of action is associated with inhibition of the activity of the angiotensin-converting enzyme, leading to a decrease in the formation of the vasoconstrictor factor - angiotensin II and simultaneously to the activation of the formation of kinin and prostacyclin possessing a vasodilating action.
It is a powerful tool which lowers cholesterol in the blood, strengthens blood vessels and fights parasites. Lasuna balances coronary function prevents the accumulation of cholesterol on the walls of the coronary arteries. The medicine stabilizes blood pressure levels. It regulates the level of lipids in plasma, the number of platelets in the blood, cholesterol and blood sugar and strengthens immunity. Strong antioxidant properties eliminate free radicals that cause an imbalance in the normal functioning of blood vessels, which should fully narrow and expand for their natural work.
Mentat improves mental functions by modulating cholinergic neurotransmission and by restoring the activity of the frontal cortical muscarinic and cholinergic receptors. It improves mental activity, memory duration, concentration ability, reduces tension and increases the detention to stress. The drug is aimed to lower the level of tribulin. It also improves the quality of attention and stabilizes behavioral reactions. Mentat provides important assistance in Parkinson's disease. Mentat improves articulation and corrects speech defects. It promotes the mental development of children.
Anti-migraine drug. Specific and selective agonist of 5-HT1-serotonin receptors, localized predominantly in the blood vessels of the brain and it does not affect other subtypes of 5-HT-serotonin receptors (5-HT2-7). Causes narrowing of the vessels of the carotid arterial bed, that supply extracranial and intracranial tissues with blood (vasodilation of the meninges and / or their edema is the main mechanism of migraine development in humans) without significantly affecting cerebral blood flow.
Mobic is a nonsteroidal anti-inflammatory drug, which has anti-inflammatory, antipyretic, analgesic effect. It belongs to the class of oxicams; derived from the anoliefo acid. Used in symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (Bekhterev's disease) and other inflammatory and degenerative diseases, accompanied by pain syndrome.