Clozaril - atypical antipsychotic medicine. Blocks dopamine receptors of CNS and interferes dopamine transfer in basal gangliya and in limbic part of neoncephalon. It is taken at Hypersensitivity, diseases of hemopoietic system (including in anamnesis), alcoholic and toxic psychosis, myasthenia, comas.
Clozaril
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Clozaril Product Description
Drug Uses
Clozaril is an atypical antipsychotic agent, providing sedative, antipsychotic, antihistamine and anticholinergic effects. Clozaril is indicated to teenagers aged 18 years and above, adults and elderly patients for treatment of:
treatment-resistant schizophrenia
psychosis during the course of Parkinson's disease
suicidal behavior in patients with schizophrenia or schizoaffective disorder
Clozaril benefits are that the drug does not virtually cause any extrapyramidal side effects such as akathisia, dystonia, bradykinesia and tremor, like other antypsyshotics do.
In contrast to classic antipsychotics, Clozaril does not increase at all or insignificantly increases the level of prolactin. Because of this, such side effects as galactorrhea, gynaecomastia and amenorrhea are normally avoided during the antipsychotic treatment with Clozaril.
To treat mental disorders, a therapeutic dose of Clozaril is recommended to be adjusted individually. At the beginning of antipsychotic therapy, low doses of Clozaril are most effective ones. For the treatment of severe mental diseases, the maximum daily Clozaril dose of 900mg can be indicated. But Clozaril doses above 450mg may significantly increase the risk of seizures and other side effects.
Missed dose
Under no circumstances should the prescribed dose of Clozaril be increased or decreased. It is stricktly not recommended to interrupt Clozaril application for more than 2 days. If you’ve forgotten to take Clozaril tablets, take the missed dose of this antipsychotic drug as soon as you remember. However, if it is nearly the time for the next prescribed dose, do not take an extra antipsychotic pill to make up the missed dose of Clozaril.
More Information
Sudden cessation of the intake of the antypsyshotic drug may cause withdrawal symptom and adverse reactions. If treatment is required to be immediately terminated (for example, in case of developing eosinophilia), gradual reduction of Clozaril dose and careful observance for the patient's mental state are recommended. Patients 60 year old and above should start the antipsychotic treatment with very low doses of Clozaril, and gradually increase the daily dose, not more than by 25mg per day.
Storage
Store the Clozaril tablets in an original container to protect them from heat and moisture. Keep Clozaril out of the reach of children at temperature not above 30°C.
Clozaril Safety Information
Warnings
During the treatment with Clozaril, severe neutropenia (abnormally low count of neutrophils) may develop in some patients, resulting in complex infection. High risk of neutropenia is observed in the first days of the antipsychotic therapy, and then is gradually decreased. Clozaril may increase the risk of seizures, so epileptic patients should take the antipsychotic with caution.
Disclaimer
Information about psychotic diseases, contained in the review of Clozaril, is
provided for the informational purposes only and should not be considered to
substitute for qualified medical care or advice of the health care provider.
The online pharmacy does not assume any liability or responsibility for damage,
arising from any use of information on atypical antipsychotic agent Clozaril.
Clozaril Side Effects
Most adverse effects of Clozaril appear only at the beginning of the antipsychotic therapy and eventually disappear. The most frequent and serious adverse effects, which Clozaril may cause include: leukocytopenia, somnolence, dizziness and psychotic disorder. Other common adverse effects of antipsychotic agent Clozaril are reported as: granulopenia, seizure triggers, cardiovascular effects, fever drowsiness/sedation, dizziness, tachyarrhythmia, constipation and ptyalism.
An anthelmintic broad-spectrum drug; most effective with enterobioze and trihozefaleze. Causes irreversible violation of glucose utilization, depletes the glycogen stores in the tissues of worms, inhibits the synthesis of cellular tubulin and also inhibits the ATP synthesis.
The antibiotic produced by Streptomyces lincolniensis, has a bacteriostatic effect. Suppresses protein synthesis of bacteria due to reversible binding to the 50S subunit of ribosomes, disrupts the formation of peptide bonds.
It is active against gram-positive cocci Streptococcus spp., including Streptococcus pneumoniae); Haemophilus influenzae; Bacillus anthracis, Mycoplasma spp., Bacteroides spp., Corynebacterium diphtheriae, Clostridium perfringens, Clostridium tetani.
Being a part of the medicine Allegra - fexofenadine it is an antihistamine with a selective antagonistic activity to H1-receptors without anticholinergic and blocking alfa1-adrenergic receptors; also at fexofenadine isn't observed a sedative action and other effects from the central nervous system. The antihistaminic effect of Allegra is observed in 1 hour, reaching its maximum in 6 hours, and proceeds within 24 hours. After 28 days of taking the medicine there wasn't observed the accustoming to it.
The medicine is blue or white tablets, the dose of the active substance is 75, 100 and 150 mg. Tablets have the bitter taste and a slight anesthetic effect on the oral mucosa. Pills may be quickly dissolved in water. Bupron is a second-generation antidepressant. Its effectiveness as an anti-nicotine drug is based on the suppression of psychological dependence on nicotine (nicotine dependence), as well as on the direct antidepressant effect, which reduces the negative manifestations that appear when a person gives up smoking.
Antidepressant. Strengthens the central adrenergic and serotonergic transfer. Used for the treatment of depressions including anhedonia, psychomotor retardation, insomnia, early awakening, weight loss, loss of interest in life, suicidal thoughts and mood swings.
Januvia - is a drug for adult patients with type 2 diabetes mellitus, in order to control the glycemic level under conditions of monotherapy as part of combined treatment regimens. The drug is prescribed to patients with ineffectiveness of diet therapy in combination with optimal physical activity, with the impossible use of metformin because of its intolerance.
Tinidazole - an antibacterial agent for systemic intake, used for the treatment of diseases such as trichomoniasis, giardiasis, amoeba dysentery, anaerobic infection, mixed aerobic-anaerobic infections (in combination with appropriate antibiotics), prevention of postoperative anaerobic infections.
Lisinopril is an antihypertensive, vasodilating, cardioprotective drug, an ACE inhibitor that is used to treat hypertension, heart failure, acute myocardial infarction, diabetic nephropathy.
Tricor - is a hypolipidemic agent, has an uricosuric and antiplatelet effect. In combination with diet therapy, the drug is prescribed for a long-term treatment, the effectiveness of which must be periodically checked by determining serum lipid levels.
A lipid-lowering agent. Reversibly inhibits HMG-COA reductase, inhibits the cholesterol synthesis at the stage of mevinolinic acid and moderately reduces its intracellular concentration. The indications for the drug use include: primary hypercholesterolemia mainly of IIa and IIb types, under the ineffective diet treatment in patients with increased risk of coronary atherosclerosis, hypercholesterolemia combined with hypertriglyceridemia; prevention of coronary artery disease. The drug decreases the risk of myocardial infarction, the need for revascularization of the myocardium, deaths from cardiovascular system diseases.
Caduet consists of Amlodipine besylate and atorvastatin calcium. Caduet has a double mechanism of action; action of amlodipin as dihydropyridinic antagonist of calcium and for suppression of atorvastatin HMG-CoA reductase. It is taken for prevention of cardiovascular events at patients with hypertension, with three concurrent factors of cardiovascular risk, with cholesterol level from normal to moderately raised, without clinical manifestations of ischemic heart disease and also when according to the existing recommendations about treatment the combined use of amlodipin and low dose of atorvastatin is deemed appropriate.
Zudena is another representative of the PDE5 inhibitors ubiquitously used in contemporary urology. It is commonly used for the therapy and prevention of erectile dysfunction. The pills contain udenafil – a reverse inhibitor of the phosphodiesterase-5, which is responsible for filling the penis with blood. This active ingredient has a range of recently introduced advantages the most notable of which are more rapid absorption (30-60 minutes) and increased half-life (starting from 10 to 12 hours, which leads to a 24-hour period of activity). The medicine may be prescribed not only for symptomatic but also for a long-term treatment.
Tadacip - an Indian brand, whose main chemical element is tadalafil, which is also a principal part of Cialis pills. It's been created by Cipla Ltd. with a more lucrative cost in comparison to Cialis made by the brand-maker Eli Lilly.
stimulant of the intestinal peristalsis. Motillium is assigned in cases of: distention, overeating, vomiting, heartburn, flatulence, a feeling of overflow of the stomach.
An antimicrobial bactericide - synthetic derivative of nitroimidazole. Used in urethritis, vaginitis, intestinal amoebiasis, liver amoebiasis, giardiasis.
Depakote - antiepileptic medicine, has the central myorelaxation and sedative effect. It is taken for treatment of epilepsy of various genesis, at epileptic seizures, febrile spasms at children, and character changes caused by epilepsy.
The drug has a thymoleptic and anxiolytic effect. Prescribed for the treatment of depressions of various origins, enuresis including the night one.
Cytoxan antineoplastic medicine of alkylating action, it has also immunodepressive effect. It is taken for treatment of small-celled lung cancer, ovarian cancer, cancer of a neck and uterus, cancer of bladder, prostate cancer, blastoma and leucosis.
The local application of Rogaine 2 has a stimulating effect on hair growth in men and women with androgenetic alopecia. In clinical studies, it is reported that Regain stimulates hair growth and stops it falling out in cases when it begins to fall from the top (men) or in the middle part (women). The stimulation of hair growth begins approximately 4 months after using the product. After the withdrawal of the drug, the growth of new hair stops. In patients with normal or high blood pressure, a local use of the medicine was not accompanied by common side effects.
Combined oral contraceptives block the action of gonadotropins. The first effect of these drugs is aimed to inhibit ovulation. The drug leads to modifications in cervical mucus. Thus, it is strenuous for sperm to pass to the uterine cavity and affect the uterine lining, thereby reducing the possibility of implementation. It helps to prevent pregnancy. Moreover, oral contraceptives prevent pregnancy and have a number of advantages. They have an impact on the cycle of menses and it becomes regular. The amount of blood loss at the time of menstruation is shorter as well as the loss of iron, dysmenorrhea is rare.
Atorlip-10 belongs to the drugs which reduce the level of low-density lipoprotein and triglycerides. Doctors identify the level with the help of blood tests. If the level is rather high, then the patients are prescribed the pills. Heart attack, strokes, high blood pressure, diabetes, and other cardiovascular diseases can be prevented thanks to the medicine. The pills are effective in case the disease is acquired due to the improper way of living or when it’s inherited.
Diabecon is aimed at increasing peripheral glucose intake, restoring B cells, increasing C – peptide levels. Diabecon has antioxidant properties, protecting cells from oxidative stress. The drug eliminates the painful symptoms of diabetes: polyuria, fever, burning feet and hands. Symptoms are eliminated not immediately after administration but within two to three weeks. This is due to changes in chemical processes in the body that cause symptoms of the disease. Diabecon naturally reduces craving for sweets, restores the patient's appetite, normalizes the functions of liver and kidney.
Trileptal is used to treat simple and complex forms of partial epileptic seizures that have secondary generalization (possibly without it) beginning at the age of one month; generalized tonic-clonic forms of epileptic seizures in patients from two years of age. Reviews about Trileptal have a positive connotation, which allows to determine its effectiveness in use, thanks to patients who have experience of taking the drug.
The medicine is a cardioselective blocker of beta-1-adrenergic receptors. A major risk index for glaucomatous scotoma is an increased tension. When its rate is soaring, the eyes are more damaged. As a consequence, a visual field narrows. Betoptic reduces both increased and usual pressure, regardless of if it occurs with glaucoma, or not; the structure of its activity is connected with a decline in the performance of intraocular fluid. Betaxolol acts after half-an-hour, and the expected result is normally achieved after 2 hours after application.
Coumadin is a drug that promotes blood thinning in the veins. Within a short period of application, anticoagulant reduces viscous blood consistency and lowers the risk of blood clots. The drug is prescribed only after laboratory blood tests when certain symptoms are detected. Independent use of tablets is prohibited, only a doctor may establish the need for taking the drug. Thrombosis is a disease that is characterized by the formation of blood clots. In case of delayed treatment, this disease may cause disorders of oxygen metabolism in the blood and embolism.
Etodolac - has an anti-inflammatory, analgesic, antipyretic effect. The medicine is prescribed in case of rheumatoid arthritis, ankylosing spondylitis, arthrosis with pain syndrome and restriction of movements, acute and chronic osteoarthritis.
Anticholinesterase agent; having a cholinesterase effect through a reversible acetylcholinesterase inhibition and enhancing the action of acetylcholine. Improves neuromuscular transmission, increases the motility of the gastrointestinal tract, increases the tone of urinary bladder, bronchi, the secretion of exocrine glands. Prescribed for myasthenia gravis, postoperative intestinal atony, atonic constipation, bladder atony, post-traumatic movement disorders; flaccid paralysis; residual explication of polio, encephalitis, violation of emptying the bladder after gynecological surgery and childbirth.
Xeloda is a cytostatic drug. The drug is used for the treatment of patients with metastatic or locally advanced breast cancer, including after an ineffective chemotherapy course, which included anthracycline drugs and taxanes, and also if the patient has contraindications to anthracyclines.
A nonsteroidal anti-inflammatory drug that has anti-inflammatory, analgesic, antipyretic action. Prescribed for inflammatory diseases of the musculoskeletal system (rheumatoid, gouty arthritis, arthritis, ankylosing spondylitis), pain syndrome (ossalgia, neuralgia, myalgia, arthralgia, sciatica, headache, dental pain, childbirth), for orthopedic surgery, cancer, algodismenorrhea, febrile syndrome.
Fosamax - drug for treatment of Paget disease, osteoporosis at women in a postmenopause, osteoporosis at men, a hypercalcemia at malignant tumors. Active alendronate ingredient - non-hormonal specific inhibitor of an osteoclastic bone resorption, suppresses osteoclasts. Taking of Fosamax stimulates bone formation, recovers positive balance between a resorption and recovery of a bone, progressively increases the mineral density of bones, promotes formation of a normal bone tissue with normal histologic structure.