Prograf The active ingredient of the drug (Tacrolimus) binds to cytosolic protein (FKBP12), responsible for the intracellular accumulation of the drug. Designed for the prevention and treatment of allograft liver, kidneys and heart rejection reactions, including those resistant to standard immunosuppressive therapy regimes.
Prograf
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Prograf Product Description
Drug Uses
Prograf is an immunosuppressant, which inhibits formation of cytotoxic lymphocytes, responsible for graft rejection. Immunosuppressant Prograf controls the body's immune response to transplantation of a new organ and reduces the risk of the transplant rejection.
Prograf is prescribed to adults and elderly patients to prevent graft rejection of allogeneic liver, kidney and/or heart. This immunosuppressant can be administered to both adults and pediatric patients.
Children aged from 4 months to 18 years can be prescribed with Prograf only to prevent liver transplant rejection. Prograf efficacy in preventing rejection of kidney and heart transplant in pediatric patients has not been proven.
The dose of immunosuppressant Prograf should be matched based on the clinical assessment of the risk of rejection, the patient’s individual tolerance and body weight. The recommended dose of immunosuppressant Prograf for adults may vary from 0.075 mg to 0.2 mg per kg of body weight per day. Prograf daily dose for infants and children with a liver transplant may vary from 0.15 mg to 0.20 mg per kg of body weight.
Missed dose
If over 6 hours have passed after the missed intake of Prograf, then skip the missed dose. Do not double a dose and do not take extra immunosuppressants to make up for the missed dose of Prograf.
More Information
Like other immunosuppressants, Prograf is characterized by high nephrotoxic potential. Therefore, regular monitoring of renal function is recommended during the immunosuppressant therapy.
Storage
Immunosuppressant Prograf should be stored in its original package at controlled room temperature below 30°C.
Prograf Safety Information
Warnings
The patients taking Prograf are considered to be at risk because of long-term use of the immunosuppressant. In long-term application of Prograf, the risk for malignancies, particularly, skin lymphoma is increased. To reduce the risk for developing lymphoma, the patients are recommended to avoid long-term exposure to sunlight and being outdoors in direct sunlight too long uncovered by clothing.
Disclaimer
Information about prevention of organ rejection, described in this review of Prograf, is provided solely as general information. This information cannot be relied as a substitute for medical advice of the transplant doctor, surgeon or other health specialist. The online pharmacy assumes no responsibility for any loss suffered by the use or misuse of information on organ rejection and Prograf.
Prograf Side Effects
Prograf may cause in the patients having kidney transplant: infection, tremor, high blood pressure, abnormal renal function, constipation, vomiting, diarrhea, headache, abdominal pain, insomnia, nausea, urinary tract infection, leucopenia, asthenia, pain or anaemia.The patients, who underwent liver or heart transplantation, may experience during the immunosuppressant therapy: paraesthesia, leukocytosis, high blood sugar, high potassium, diabetes, itch or abnormalities of magnesium levels.
Vermox - anthelminthic drug of a wide spectrum of action. The most effective for Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Taenia solium, Echinococcus granulosus, Echinococcus multilocularis, Trichinella spiralis, Trichinella nativa, Trichinella nelsoni.
Causing an irreversible violation of glucose utilization, depletes glycogen stores in helminth tissues, interferes with the synthesis of cellular tubulin, and also inhibits the synthesis of ATP.
Capoten suppresses activity of angiotensin-converting-enzyme therefore angiotensin-I turns into angiotensin II - substance which has strong vasoconstrictive action. Capoten reduces secretion of Aldosteronum in suprarenal cortex, at the same time the delay of sodium and water in an organism decreases. Capoten slows down process of bradykinin destruction and promotes increase of E2 prostaglandin, and also nitrogen oxide that causes vasodilating action. Thanks to these effects it is decreased the increased arterial pressure, the general peripheric resistance decreases, pressure in the right auricle, in a small circle of blood circulation decreases and cordial emission increases.
Avapro - the remedy which is used separately or in combination with other drugs for treatment of high blood pressure. It is also used for treatment of diseases of kidneys caused by diabetes mellitus 2 type (the state at which the organism can't use insulin normally and, therefore, can't control amount of sugar in blood) and high blood pressure. Irbesartan in a class of the drugs called antagonists of receptors of angiotensin II. It works by blocking of effects of some natural substances which tighten blood vessels that allows blood flow more smoothly and the heart works more effectively.
A semi-synthetic antibiotic from the macrolides group for oral administration. The list of indications includes: infections of the upper and lower respiratory tract (pharyngitis, bronchitis, pneumonia, bacterial infection in COPD, panbronchiolitis, bronchiectasis), respiratory tract (tonsillitis, sinusitis, otitis media), skin and soft tissues (erysipelas, phlegmon, furuncles, folliculitis, impetigo, pyoderma), urinary tract (urethritis, endometritis, cervicitis, vaginitis, including sexually transmitted infections, except gonorrhea), oral cavity (periodontitis), bones (periostitis, chronic osteomyelitis); scarlet fever, diphtheria, whooping cough, trachoma, migratory erythematous rash, brucellosis.
Altace, which is Antihypertensive (the reducing arterial pressure) medicine, inhibitor of angiotensine transforming enzyme. Suppressing angiotensin II synthesis, narrowing a luminal occlusion also reduces its stimulating influence on effuse of aldosteron. Increases activity of a renin in plasma. The medicine also inhibits metabolism (interferes with decomposition in an organism) of bradykinin. Medicine reduces the general vascular peripheral resistance, does not change significantly a renal blood flow.
Seroquel - treats acute and chronic psychoses, including schizophrenia. The drug is also prescribed to patients with manic episodes associated with bipolar disorders.
An antidepressant means, which selectively inhibits the reuptake of serotonin (5-HT) in the central nervous system, enhances serotonergic transmission in the CNS. Used to treat depressions of various etiologies (including anxious, reactive, recurrent, atypical and post-psychotic, depressive episodes of bipolar disorder, dysthymia, depression on the background of schizophrenia, organic CNS diseases and alcoholism).
An oral hypoglycemic means, which inhibiting the intestinal alpha-glycosidase, reduces the enzymatic conversion of di-, oligo - and polysaccharides to mono-saccharides, thereby reducing the absorption of glucose from the intestine and postprandial hyperglycemia. It is used to treat diabetes, of type 2 under the ineffective diet, the course of which shall not be less than 6 months, type 1diabetes within the combination therapy.
The oral hypoglycemic agent, which stimulates insulin release from functioning beta cells of the pancreas. Used for the treatment of diabetes mellitus type 2 under the ineffectiveness of diet, weight loss and physical activity.
Ceftin - the antibiotic cephalosporin, is prescribed for treatment of Bacterial infections caused by sensitive microorganisms: respiratory diseases (bronchitis, pneumonia, abscess of lungs, a pleura empyema, etc.), ENT organs (sinusitis, tonsillitis, pharyngitis, otitis, etc.), urinary tract (pyelonephritis, cystitis, asymptomatic bacteriuria, gonorrhea, etc.), skin and soft tissues (face, pyoderma, impetigo, furunculosis, phlegmon, a wound fever, diamond-skin disease, etc.), bones and joints (osteomyelitis, septic arthritis, etc.), small pelvis (endometritis, adnexitis, cervicitis), sepsis, meningitis, Lyme desease (borreliosis), prevention of infectious complications at operations on Thoracic organs, abdominal cavity, pelvis, joints inc. at operations.
Benicar is a drug that is prescribed for essential arterial hypertension. In case of arterial hypertension, olmesartan causes a dose-dependent long-term reduction of a blood pressure.
A receptors blocker angiotensin II (AT1 type). Has a vasodilating and hypotensive effect. Does not show the properties of the agonist of angiotensin receptors, does not affect the state of ionic channels involved in the regulation of SSS. Does not inhibit ACE. Decreases both systolic and diastolic blood pressure without affecting the pulse rate. The start of antihypertensive action is in 3 hours, a steady decrease of the blood pressure is in 4 weeks after the start of the treatment. The duration of the hypotensive effect after a single intake is 24 hours.
Crestor - is a lipid-lowering drug that reduces the elevated cholesterol concentrations in the body.
Viagra - Active ingredient - Sildenafil, 100 mg. Effect of "Viagra" is based on significant increase of blood stream to penis. Begins to work in 30 minutes, the effect lasts for 4-5 hours. Most of men can take this generic viagra every day. Millions of men worldwide cannot be mistaken, choosing Viagra!
An antiaggregant, used for the prevention of thrombotic complications in patients with acute coronary syndrome (ACS), who are planned to undergo percutaneous coronary angioplasty and for prevention of stent thrombosis in acute coronary syndromes. The medicine is a receptor antagonist of P2Y12class to adenosine diphosphate (ADP), and consequently inhibits the activation and aggregation of platelets. Since platelets are involved in the development of atherosclerosis complications, the inhibition of platelet function may lead to a decrease in the frequency of cardiovascular complications.
Kemadrin is a medicinal substance similar in its effect to atropine; It is used to reduce tremor and rigidity of muscles in Parkinsonism.
Finast is indicated for the treatment of benign proliferation of prostate tissue with the purpose of reducing its size and slowing the pathological process. The drug is successfully used to normalize the outflow of urine in case of a benign prostate enlargement and accompanying symptoms of hyperplasia. Finast is recommended for patients with benign enlargement of the prostate for the prevention of complications, urinary retention and the need for surgery. Under the influence of Finast, the level of dihydrotestosterone decreases in the blood and in the tissues of the prostate, but the drug does not affect the androgen receptors.
Dutas is a mix of two medicines: dutasteride and tamsulosin hydrochloride. The drugs have complementary mechanisms of action, due to which there is a rapid weakening of urination. It reduces the risk of retention of the urine. It is not anticipated that the pharmacodynamic reactions of a fixed dosage mix of dutasteride-tamsulosin differ from those obtained with the simultaneous use of dutasteride and tamsulosin as separate elements. Dutasteride inhibits the activity of both the 1st and 2nd type of isoenzymes. DHT is an androgen that is responsible for prostate and the increase of BPH. It inhibits the activity of adrenoreceptors.
Diovan - the peripheral vasodilator, has hypotensive effect. The specific blocker of AT1 receptors of angiotensin II, does not inhibit ACE; does not influence the level of general cholesterol, TG, glucose and uric acid in blood.
It is a powerful tool which lowers cholesterol in the blood, strengthens blood vessels and fights parasites. Lasuna balances coronary function prevents the accumulation of cholesterol on the walls of the coronary arteries. The medicine stabilizes blood pressure levels. It regulates the level of lipids in plasma, the number of platelets in the blood, cholesterol and blood sugar and strengthens immunity. Strong antioxidant properties eliminate free radicals that cause an imbalance in the normal functioning of blood vessels, which should fully narrow and expand for their natural work.
Finax (finasteride) is a drug designed to treat hair loss in men. This drug can slow down the process of baldness and promote the growth of new hair on the scalp in men who suffer from androgenic alopecia. It acts by blocking the activity of the enzyme 5-alpha-reductase in the body which prevents the formation of dihydrotestosterone (a male sex hormone that is the active form of testosterone, formed from testosterone in bodily tissue). The drug is also used in the treatment of difficulty urinating caused by a prostate adenoma (BPH, benign prostatic hyperplasia).
Keppra - antiepileptic drug, the mechanism of action is unclear, it does not alter normal synaptic transmission. Effective in both focal and epilepsy (epileptiform manifestations, photo paroxysmal reaction).
Mentat improves mental functions by modulating cholinergic neurotransmission and by restoring the activity of the frontal cortical muscarinic and cholinergic receptors. It improves mental activity, memory duration, concentration ability, reduces tension and increases the detention to stress. The drug is aimed to lower the level of tribulin. It also improves the quality of attention and stabilizes behavioral reactions. Mentat provides important assistance in Parkinson's disease. Mentat improves articulation and corrects speech defects. It promotes the mental development of children.
Zyprexa is an antipsychotic drug used mainly to treat severe mental conditions, most notably schizophrenia. This oral medication normalizes the balance of chemical compounds in the brain, especially when used in combination with other antipsychotics. The active ingredient, which is a ligand for serotonin and dopamine receptors, provides also a selective impact on the functioning of the limbic system. The target group of the drug is not limited to the cases with extra severity – the pills may be prescribed for people with moderate mood or nervous conditions as well.
A blocker of H1-histamine receptors of the first generation, derived from ethanolamine; eliminates the effects of histamine, mediated through this type of receptors. Promotes the local anaesthesia (when intaken, there is a short numbing of the mucous membranes in the mouth) - only in high doses, it blocks m-cholinergic receptors in the central nervous system, has sedative, hypnotic, antiemetic and antiparkinsonian effects. The therapeutic indications include: allergic conjunctivitis, allergic rhinitis, chronic urticaria, pruritic dermatoses, dermatographism, serum sickness.
Shallaki offers a herbal cure for sore joints and is based on an extract from Boswellia serrate. Completely natural origin of the medicine guarantees its safety and pure benefits for the body. It is a powerful auxiliary remedy applied in the treatment of arthritis as well as prevention of joint conditions. Shallaki alleviates pain and swelling in areas of inflammation and lowers the overall level of triglyceride and cholesterol with high efficiency. Its health-promoting behavior makes it a great aid for weight reduction.
Voveran is one of the analgesic agents used mostly in the therapy of different painful conditions. The main indications for use of this anti-inflammatory medicine include arthritis, muscle pain, and migraines of different origin. The treatment of other pain syndromes may also require the use of this drug upon the therapist’s consideration. This is a non-steroidal medicine, which expands the spheres of its possible use in comparison with steroidal drugs, most notably in late-middle-aged people. The pills are not habit-forming; however, the misuse, as well as the long-term course of treatment, is prohibited.
Mobic is a nonsteroidal anti-inflammatory drug, which has anti-inflammatory, antipyretic, analgesic effect. It belongs to the class of oxicams; derived from the anoliefo acid. Used in symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (Bekhterev's disease) and other inflammatory and degenerative diseases, accompanied by pain syndrome.
Prednisone - is a drug from the group of hormones of the adrenal cortex (glucocorticosteroids). It contains prednisolone as the main substance. It is prescribed to patients who suffer from: Bechterew's disease, inflammatory changes in the spinal cord and membranes, non-infectious arthritis, edematous processes of the vertebrae and its structures, osteoarthrosis, severe soreness in the spine, spinal and nerve injuries of the spine, osteochondrosis.
AyurSlim is a clinically tested, 100% safe natural slimming product with no side effects. Developed by Himalaya Herbal Healthcare, a leader in the production of herbal products based on scientific research, AyurSlim promotes weight loss and has a beneficial effect on fat structures. This plant product is safe and effective and is carefully studied by science. In addition, help to lose weight, it improves fat structure, which in turn helps to delay the appearance of cardiovascular problems, as well as the deposition of fat inside the arteries (cholesterol deposits), providing additional health benefits.
Prometrium is used as part of hormone replacement therapy for women who underwent menopause (menopause) and did not have a hysterectomy (surgical removal of the uterus). Prometrium is also used to cause menstruation for women of childbearing age.
Clomid - anti-estrogen of nonsteroid structure which is taken for treatment of anovular infertility, dysfunctional metrorrhagia, amenorrhea, secondary amenorrheas, post-contraceptive amenorrheas, galactorrhoea (against the background of hypophysis tumor), syndrome of polycystic ovaries (sclerocystic disease of the ovary), Chiari-Frommel disease, androgenic insufficiency, oligospermatism, diagnosis of disturbances of gonadotropic function of hypophysis.
Fertomid an antiestrogenic medical remedy of a nonsteroidal structure. It is called to activate the ovulation in an infertile female due tosecond-rate ovarian hypo-function, mainly purposed by the functional hypothalamic-hypophyseal disorders. Used to cure anovulatory disorders of cycles of central hypothalamic origin, second-rate amenorrhea of different etiology, menstrual disorder. It is assigned in cases of amenorrhea after the use of contraceptives, the pathological spontaneous outflow of the breast milk not connected with a baby breastfeeding, the syndrome of Stein-Leventhal, Chiari-Frommel syndrome, and oligospermia.