It is a sulfonamide diuretic that is pharmacologically related to thiazide diuretics. The medicine inhibits sodium reabsorption in the cortical segment of the kidneys. It increases the excretion of sodium and chlorides in the urine and the excretion of potassium and magnesium, thus increasing diuresis. The antihypertensive effect of the active components appears at doses at which the diuretic effect is insignificant. Moreover, its antihypertensive effect persists even in patients with hypertension.
Lozol
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The tablets are aimed at reducing the ability of smooth muscle vessels to contract and to stimulate the synthesis of prostaglandin PGE2 and prostacyclin PGI2 (vasodilator and platelet aggregation inhibitor).
Product Description
The pills increase the excretion of sodium in the urine, and to a lesser extent the release of magnesium and potassium. Thus the action of diuresis becomes faster. The effect of the drug persists even in people with hypertension. The medicine operates at the level of the vessels. It decreases the contractility of the muscles of blood vessels, stimulates indapamide in blood vessels, and reduces left ventricular hypertrophy.
According to studies that had different duration-short, medium and long, it has been determined that the pills do not affect the metabolism of lipids, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein; they do not influence the metabolism of carbohydrates, even in patients with hypertension and diabetes. If the recommended dose is exceeded, then the therapeutic effect of the components of the tablet will not be greater and the frequency of adverse reactions will increase. One should not increase the dose if the treatment is ineffective.
Safety Information
The tablets are not recommended and are contraindicated for people who have a high sensitivity to them or any other excipients. The pills are not recommended for people with severe renal insufficiency, with severe liver function disorders, with hypokalemia. It is not advised to combine medicine with lithium at a high level of its concentration in plasma may appear. They will be together with the symptoms of overdose with a salt-free diet. If you are appointed a diuretic, it is necessary to conduct a thorough study of the level of lithium in the blood.
If you take pills with the drugs mentioned above, there is a risk of gastric arrhythmia and gastric tachycardia or hypokalemia. Before taking this combination of tablets you need to check the level of potassium and correct it to a normal level if necessary. It is also necessary to control the level of plasma electrolytes. If there is hypokalemia, you need to take drugs that do not cause wave burst arrhythmia.
The best time for taking remedy is in the morning, 1 tablet (0.0015 g), without grinding, without chewing and washing with a ½ cup of water. The maximum daily dose - 1 tablet (0.0015 g).
Side Effects
A large number of negative effects (clinical or laboratory parameters are known to depend on the dose of the pill) can cause such adverse reactions as:
- Thrombocytopenia, hemolytic anemia, leukopenia, agranulocytosis;
- Dizziness (vertigo), fatigue, headache, paresthesia; fainting.
- Arrhythmia, hypotension; paroxysmal ventricular tachycardia;
- Vomiting; nausea, constipation, dry mouth; pancreatitis;
- Renal failure.
Patients with hypersensitivity who had a high predisposition to allergies and asthma, maculopapular rash; purpura; angioedema and/or urticaria, toxic epidermal necrolysis.
The antibiotic produced by Streptomyces lincolniensis, has a bacteriostatic effect. Suppresses protein synthesis of bacteria due to reversible binding to the 50S subunit of ribosomes, disrupts the formation of peptide bonds.
It is active against gram-positive cocci Streptococcus spp., including Streptococcus pneumoniae); Haemophilus influenzae; Bacillus anthracis, Mycoplasma spp., Bacteroides spp., Corynebacterium diphtheriae, Clostridium perfringens, Clostridium tetani.
A drug for the prevention and treatment of HIV infection. An antiviral agent, which competitively blocks the reverse transcriptase and selectively inhibits the replication of viral DNA.
Accupril, which is quinapril, medication with hypotensive, natriuretic, cardio-protecting effect and vasodilating properties. It is used in case of an arterial hypertension (mono- or combined therapy), heart failure (combined therapy).
Aristocort - glucocorticoid drug (the adrenal hormone influencing carbohydrate and protein metabolism). Renders prominent antiinflammatory, antiallergic and immunodepressive (suppressing immunity - body defences of an organism) effect. It is prescribed at rheumatism, allergic reactions, multiform erythema (variously proceeding skin disease which occurs with rubefaction of affected area of skin), pseudorheumatism (the infectious and allergic disease from a group of collagenoses which is characterized by chronic progressing inflammation of joints); systemic lupus erythematosus and other collagenoses.
Anafranil, which is clomipramine - is a tricyclic antidepressant. Clomipramine has antiserotonin effect, it eliminates night enuresis, causes loss of appetite. Sedative action is shown due to linkng with H1-histamine receptors, blocking of alpha-adrenoceptors. Medicine eliminates arrhythmia, slows down ventricular conductivity. The anti-depressive effect is implemented due to increase in concentration of noradrenaline, serotonin in synapses because of weakening of the process of recapture of these substances by presynaptic neurons.
Glucotrol peroral hypoglycemic medicine. It is taken at a diabetes mellitus of type 2 (at inefficiency of dietotherapy). It has pancreatic and extra pancreatic effects. Stimulates secretion of insulin by reductions of the threshold of irritation with glucose of beta cells of pancreas, increases sensitivity to insulin and extent of its linkng with target cells, increases insulin release, strengthens influence of insulin on glucose absorption by muscles and liver, brakes lipolysis in fatty tissue.
Diflucan - antifungal medicine, possesses highly specific action, inhibiting activity of enzymes of fungus. It is taken at systemic lesions caused by fungus including meningitis, sepsis, infections of lungs and skin as at patients with a normal immune response, and at patients with various forms of immunosuppression.
Hyzaar - complex hypertensia medicine. A hydrochlorothiazide - Thiazide diuretic of average force and losartan - hypotensive drug which is specific blocker angiotensin II (AT1 type) of receptors. Does not suppress a kinase II - enzyme destroying bradykinin.
Tricor - is a hypolipidemic agent, has an uricosuric and antiplatelet effect. In combination with diet therapy, the drug is prescribed for a long-term treatment, the effectiveness of which must be periodically checked by determining serum lipid levels.
Zudena is another representative of the PDE5 inhibitors ubiquitously used in contemporary urology. It is commonly used for the therapy and prevention of erectile dysfunction. The pills contain udenafil – a reverse inhibitor of the phosphodiesterase-5, which is responsible for filling the penis with blood. This active ingredient has a range of recently introduced advantages the most notable of which are more rapid absorption (30-60 minutes) and increased half-life (starting from 10 to 12 hours, which leads to a 24-hour period of activity). The medicine may be prescribed not only for symptomatic but also for a long-term treatment.
The main effect of Top Avana lies in the sustainment of a sexually productive penile erection. Its extra benefit in males consists in a significant enlargement of the coitus and postponement of ejaculations. The drug’s component Avanafil inhibits the body chemical preventing an ED patient from getting an erection. Avanafil enzymatically enhances the circulation and lets the corpus cavernosum stay pumped with blood.
Cialis Professional - effective tablets for improvement of erection. They begin to work in 15 minutes from the moment of taking and actions for 36 hours. They can cause not less than 10, but no more than 16 erections. The medicine increases duration of sexual intercourse. The tablets are successfully used for reduction of time for recovery of erection after ejaculation.
Gastroprotective agent, a synthetic analog of PgE1 boosts the formation of defensive slime and bicarbonate; enhances blood flow in the mucosa. It stimulates the healing of erosions, gastric and duodenal ulcers and is able to prevent their formation in some cases. It has a direct impact on the parietal cells of the abdomen, inhibits the lowest, and stimulated (by meal,pentagastrin, histamine) excretion of HCl. he drug diminishes the basal production of pepsin. The expected result occurs after 30 minutes and lasts at least 3-6 hours.
stimulant of the intestinal peristalsis. Motillium is assigned in cases of: distention, overeating, vomiting, heartburn, flatulence, a feeling of overflow of the stomach.
Methocarbamol – a muscle relaxant used to treat muscle spasms and pain. Its action is to block pain nerve impulses sent to the brain. The mechanism of action is not completely clear. The drug has no direct effect on skeletal muscles. It's likely that its effect is associated with sedative properties.
Trecator SC - an anti-TB drug (antituberculous), contains Ethionamide as a basic substance, the drug is prescribed for the treatment of multidrug-resistant type of tuberculosis, with the mycobacterium tuberculosis susceptible to it.
Depakote - antiepileptic medicine, has the central myorelaxation and sedative effect. It is taken for treatment of epilepsy of various genesis, at epileptic seizures, febrile spasms at children, and character changes caused by epilepsy.
Cordarone - antiarrhytmic drug of III class (repolarization inhibitor). Possesses also anti-anginal, coronarodilator, alpha and beta, adrenoceptor blocking and hypotensive action. The anti-anginal effect of Cordarone is caused by coronarodilator and anti-adrenergic action, reduction of need of a myocardium for oxygen.
Topamax - the remedy with an active ingredient: topiramate, it is used as a monotherapy for the treatment of adults and children 6 years of age with partial attacks with or without secondary generalized seizures and primary generalized tonic-clonic seizures; as an adjunct therapy for the treatment of adults and children 2 years of age with partial attacks with or without secondary generalized seizures or primary generalized tonic-clonic seizures and the treatment of attacks associated with Lennox-Gasto syndrome; to prevent migraine attacks in adults, after careful evaluation of alternative treatment options. Topiramate is not recommended for the treatment of acute conditions.
Antiepileptic agent. The use of Lamictal reduces the pathological activity of neurons without inhibiting their function. Stabilizes the neuronal membranes by affecting Na + channels, blocks excessive release of excitatory amino acids (mainly glutamate), without reducing its normal release.
Olanzapine is an antipsychotic drug (neuroleptic). It is shown in schizophrenia in adults, psychotic disorders, bipolar affective disorder in adults, depressive states.
The local application of Rogaine 2 has a stimulating effect on hair growth in men and women with androgenetic alopecia. In clinical studies, it is reported that Regain stimulates hair growth and stops it falling out in cases when it begins to fall from the top (men) or in the middle part (women). The stimulation of hair growth begins approximately 4 months after using the product. After the withdrawal of the drug, the growth of new hair stops. In patients with normal or high blood pressure, a local use of the medicine was not accompanied by common side effects.
Propecia - an anti-hormonal drug. Used to reduce the size of the prostate gland, to increase the maximum speed of urine outflow, reducing the risk of developing acute urinary retention. The drug also turned out to be effective in the treatment of men’s alopecia.
Finpecia - potent pharmaceutical agent aimed to cure an illness named alopecia, of an androgenic as well as a hereditary genesis. Moreover, it stops the manifestation of various maladies deteriorating the advancement of the follicles and other difficulties connected with baldness.
Cardizem, derivative benzothiazepine, has anti-anginal, antiarrhytmic and hypotensive effect. It is prescribed at arterial hypertension: after myocardial infarction, at patients with accompanying stenocardia when beta adrenoblockers, are contraindicative at patients with diabetic nephropathy, in cases when ACE inhibitors are contraindicated; angina of effort, Prinzmetal's angina; prevention of a coronary spasm when carrying out a coronary angiography or operation of aortocoronary shunting.
Atorlip-5 is a drug which purpose is to lower the level of so-called bad cholesterol in the human organism. Its amount is identified due to the blood testing. The accumulation of low-density lipoprotein can lead to atherosclerosis. As the result, arteries are getting narrow causing cardiovascular complications as strokes, heart attacks, hypertonia, and peripheral artery disease. Liver fat can be also reduced thanks to the drugs. The other benefit is that the medicine increases the level of high-density lipoprotein.
Uroxatral - Alfuzosinis an active substance, as an antagonist of the α1 adenogenetic receptor, this drug relaxes the muscles of the prostate and the bladder. Used in the treatment of benign prostatic hyperplasia (BPH). Reduces pressure in the urethra and reduces resistance to urine flow, eases urination and eliminates dysuria.
Hytrin refers to the group of pharmaceutical products intended to cure the sexual/urinary maladies and sex hormone medical preparations. Its composition includes Terazozin - a medical mean for the normalization of the prostate gland in benign hypertrophy.
Trileptal is used to treat simple and complex forms of partial epileptic seizures that have secondary generalization (possibly without it) beginning at the age of one month; generalized tonic-clonic forms of epileptic seizures in patients from two years of age. Reviews about Trileptal have a positive connotation, which allows to determine its effectiveness in use, thanks to patients who have experience of taking the drug.
Colchicine is a means that affects the metabolism of uric acid, which contains the active substance: colchicine. Colchicine tablets are used for the treatment of acute gout attacks and prevention of acute attacks of gout in the initial treatment with allopurinol drugs or drugs that contribute to the excretion of uric acid. A single initial dose of the drug is 1 mg, then-0.5 mg every 2-3 hours until pain relief. This drug is contraindicated for people during pregnancy, breastfeeding, and children.
Etodolac - has an anti-inflammatory, analgesic, antipyretic effect. The medicine is prescribed in case of rheumatoid arthritis, ankylosing spondylitis, arthrosis with pain syndrome and restriction of movements, acute and chronic osteoarthritis.
Voveran SR is the special formulation of Voveran, developed for the suspended release of its active ingredients and, consequently, a prolonged period of action. Apart from this feature, it has no notable characteristics differentiating it from the original medicine – an analgesic that provides satisfying results in the treatment of moderate pain syndromes. It helps with a wide range of painful conditions allowing patients to stop the pain before it grows stronger or control it in case of chronic joint diseases. In general, the new form provides better results in particular in the treatment of prolonged pain.
Xeloda is a cytostatic drug. The drug is used for the treatment of patients with metastatic or locally advanced breast cancer, including after an ineffective chemotherapy course, which included anthracycline drugs and taxanes, and also if the patient has contraindications to anthracyclines.
A nonsteroidal anti-inflammatory drug that has anti-inflammatory, analgesic, antipyretic action. Prescribed for inflammatory diseases of the musculoskeletal system (rheumatoid, gouty arthritis, arthritis, ankylosing spondylitis), pain syndrome (ossalgia, neuralgia, myalgia, arthralgia, sciatica, headache, dental pain, childbirth), for orthopedic surgery, cancer, algodismenorrhea, febrile syndrome.
Fosamax - drug for treatment of Paget disease, osteoporosis at women in a postmenopause, osteoporosis at men, a hypercalcemia at malignant tumors. Active alendronate ingredient - non-hormonal specific inhibitor of an osteoclastic bone resorption, suppresses osteoclasts. Taking of Fosamax stimulates bone formation, recovers positive balance between a resorption and recovery of a bone, progressively increases the mineral density of bones, promotes formation of a normal bone tissue with normal histologic structure.
Fluoxetine is an antidepressant group of selective serotonin reuptake inhibitors. It has a timoanaleptic and stimulating effect. It is used for depression of various genesis, obsessive-compulsive disorders, bulimic neuroses.