Thiol derivative, a competitive hypoxanthine antagonist, has an immunosuppressive and cytostatic effect. It is used for prevention of rejection reaction in kidney transplantation, treatment of rheumatoid arthritis, chronic active hepatitis, SLE, dermatomyositis, periarteritis nodosa, acquired hemolytic anemia, gangrenous pyoderma, psoriasis, Crohn's disease, ulcerative colitis and myopathy.
Imuran
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Imuran Product Description
Drug Uses
Imuran is an immunosuppressive agent used for the suppression of immune responses in the treatment of autoimmune diseases or after organ transplantation. Imuran tablets can be used alone, or as a part of combined immunomodulatory therapy.
As an immunosuppressive antimetabolite, Imuran is approved as:
- Prevention of rejection of transplanted organs and improved survival after organ transplantation (including for medical management of renal, cardiac and hepatic transplant recipients).
- Management of active, severe, inflammatory and chronic autoimmune diseases of joints, skin, skeletal muscles, blood cells, arteries, liver and other organs and body systems.
Imuran maintenance dose to prevent transplant rejection ranges from 1mg to 4mg (once a day). The maintenance daily doses of Imuran for patients with autoimmune diseases vary from 1mg to 3mg (as a single or two divided doses).
Missed dose
If you take Imuran several times a day and skip a regular dose, take it as soon as you remember. Do not double Imuran dose and do not take extra immunosuppressive drugs to make up the missed dose.
More Information
To prevent transplant rejection, Imuran can be used together with other immunosuppressive agents. For symptomatic treatment of autoimmune diseases, Imuran can be used together with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs).
Storage
Imuran tablets should be protected from direct sunlight and stored in a dry place, at room temperature not exceeding 30°C.
Imuran Safety Information
Warnings
Drugs suppressing immune responses (such as, Imuran) may increase the risk of developing malignancies. Patients with high risk of malignancies should be prescribed with Imuran only if the benefits of immunosuppressive therapy outweigh the potential risks.
Disclaimer
Data about immunosuppressive therapy represented in this Imuran review is intended only for general information. This information in no case does not constitute an offer of a substitute for the immunologist’s professional medical advice or diagnosis of immune diseases. The online pharmacy shall not be held responsible for any damages resulting from the use of information about transplantation, autoimmune diseases and Imuran.
Imuran Side Effects
Imuran adverse reactions are reversible and disappear when decreasing the dose or duration of immunosuppressive therapy. The most severe adverse reactions of Imuran are hematologic and gastrointestinal disorders, such as leucopenia, infection, anemia, nausea, vomiting, hepatic toxicity, diarrhea, fever, malaise, vasculitis or muscle pain. Less often, Imuran may cause skin rashes, hair loss, fever, joint pain, steatorrhea, infections (e.g. viral, fungal and bacterial) or exanthem.
Vermox - anthelminthic drug of a wide spectrum of action. The most effective for Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Taenia solium, Echinococcus granulosus, Echinococcus multilocularis, Trichinella spiralis, Trichinella nativa, Trichinella nelsoni.
Causing an irreversible violation of glucose utilization, depletes glycogen stores in helminth tissues, interferes with the synthesis of cellular tubulin, and also inhibits the synthesis of ATP.
Altace, which is Antihypertensive (the reducing arterial pressure) medicine, inhibitor of angiotensine transforming enzyme. Suppressing angiotensin II synthesis, narrowing a luminal occlusion also reduces its stimulating influence on effuse of aldosteron. Increases activity of a renin in plasma. The medicine also inhibits metabolism (interferes with decomposition in an organism) of bradykinin. Medicine reduces the general vascular peripheral resistance, does not change significantly a renal blood flow.
Astelin belongs to antihistamines which purpose is to block histamines in the human organism. It’s a spray that deletes nasal congestion, itching, and sneezing. The medicine is effective in case of infection, inflammation, and allergic reaction which result in itching, stuffy, and runny nose. Medics usually prescribe it for adults and children above five (in case of seasonal allergy) and above twelve (in case of vasomotor rhinitis that constricts and dilates a vein, artery, or capillary in the nasal cavity).
An antidepressant means, which selectively inhibits the reuptake of serotonin (5-HT) in the central nervous system, enhances serotonergic transmission in the CNS. Used to treat depressions of various etiologies (including anxious, reactive, recurrent, atypical and post-psychotic, depressive episodes of bipolar disorder, dysthymia, depression on the background of schizophrenia, organic CNS diseases and alcoholism).
The oral hypoglycemic agent, derived from sulfonylureas of the II generation. Used in complex therapy with insulin to control the blood glucose levels daily in diabetes of the second type. Has pancreatic and extrapancreatic effects. Stimulates the secretion of insulin by lowering the threshold of pancreas beta cells’ stimulation by glucose, improves insulin sensitivity and the degree of its binding to target cells, increases insulin release, enhances the effect the insulin has on glucose uptake by muscle and liver, inhibits lipolysis in the adipose tissue.
The oral hypoglycemic agent, which stimulates insulin release from functioning beta cells of the pancreas. Used for the treatment of diabetes mellitus type 2 under the ineffectiveness of diet, weight loss and physical activity.
Cleocin has bacteriostatic and bactericidal activity depending on concentration of drug, infectious process and condition of an organism of the patient. Active against aerobic and anaerobic streptococcus (except for enterococci), the majority of staphylococcus except for methicillin-resistant strains, bacteroids except for Bacteroides melaninogenicus, spindle-shaped bacteria
Benicar is a drug that is prescribed for essential arterial hypertension. In case of arterial hypertension, olmesartan causes a dose-dependent long-term reduction of a blood pressure.
A receptors blocker angiotensin II (AT1 type). Has a vasodilating and hypotensive effect. Does not show the properties of the agonist of angiotensin receptors, does not affect the state of ionic channels involved in the regulation of SSS. Does not inhibit ACE. Decreases both systolic and diastolic blood pressure without affecting the pulse rate. The start of antihypertensive action is in 3 hours, a steady decrease of the blood pressure is in 4 weeks after the start of the treatment. The duration of the hypotensive effect after a single intake is 24 hours.
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An antiaggregant, used for the prevention of thrombotic complications in patients with acute coronary syndrome (ACS), who are planned to undergo percutaneous coronary angioplasty and for prevention of stent thrombosis in acute coronary syndromes. The medicine is a receptor antagonist of P2Y12class to adenosine diphosphate (ADP), and consequently inhibits the activation and aggregation of platelets. Since platelets are involved in the development of atherosclerosis complications, the inhibition of platelet function may lead to a decrease in the frequency of cardiovascular complications.
Kemadrin is a medicinal substance similar in its effect to atropine; It is used to reduce tremor and rigidity of muscles in Parkinsonism.
Diovan - the peripheral vasodilator, has hypotensive effect. The specific blocker of AT1 receptors of angiotensin II, does not inhibit ACE; does not influence the level of general cholesterol, TG, glucose and uric acid in blood.
Plavix is an antiplatelet drug; specific and active inhibitor of platelet aggregation; has a coronary-dilating effect. The use of Plavix is indicated for the prevention of atherothrombotic complications in adult patients with myocardial infarction in adult patients with an acute coronary syndrome. The drug is also indicated to prevent atherothrombotic and thromboembolic complications, including a stroke, atrial fibrillation in patients with atrial fibrillation, who have at least one risk factor for vascular complications and who cannot take indirect anticoagulants and have a low risk of bleeding.
Keppra - antiepileptic drug, the mechanism of action is unclear, it does not alter normal synaptic transmission. Effective in both focal and epilepsy (epileptiform manifestations, photo paroxysmal reaction).
Zyprexa is an antipsychotic drug used mainly to treat severe mental conditions, most notably schizophrenia. This oral medication normalizes the balance of chemical compounds in the brain, especially when used in combination with other antipsychotics. The active ingredient, which is a ligand for serotonin and dopamine receptors, provides also a selective impact on the functioning of the limbic system. The target group of the drug is not limited to the cases with extra severity – the pills may be prescribed for people with moderate mood or nervous conditions as well.
A blocker of H1-histamine receptors of the first generation, derived from ethanolamine; eliminates the effects of histamine, mediated through this type of receptors. Promotes the local anaesthesia (when intaken, there is a short numbing of the mucous membranes in the mouth) - only in high doses, it blocks m-cholinergic receptors in the central nervous system, has sedative, hypnotic, antiemetic and antiparkinsonian effects. The therapeutic indications include: allergic conjunctivitis, allergic rhinitis, chronic urticaria, pruritic dermatoses, dermatographism, serum sickness.
Shallaki offers a herbal cure for sore joints and is based on an extract from Boswellia serrate. Completely natural origin of the medicine guarantees its safety and pure benefits for the body. It is a powerful auxiliary remedy applied in the treatment of arthritis as well as prevention of joint conditions. Shallaki alleviates pain and swelling in areas of inflammation and lowers the overall level of triglyceride and cholesterol with high efficiency. Its health-promoting behavior makes it a great aid for weight reduction.
Voveran is one of the analgesic agents used mostly in the therapy of different painful conditions. The main indications for use of this anti-inflammatory medicine include arthritis, muscle pain, and migraines of different origin. The treatment of other pain syndromes may also require the use of this drug upon the therapist’s consideration. This is a non-steroidal medicine, which expands the spheres of its possible use in comparison with steroidal drugs, most notably in late-middle-aged people. The pills are not habit-forming; however, the misuse, as well as the long-term course of treatment, is prohibited.
Prednisone - is a drug from the group of hormones of the adrenal cortex (glucocorticosteroids). It contains prednisolone as the main substance. It is prescribed to patients who suffer from: Bechterew's disease, inflammatory changes in the spinal cord and membranes, non-infectious arthritis, edematous processes of the vertebrae and its structures, osteoarthrosis, severe soreness in the spine, spinal and nerve injuries of the spine, osteochondrosis.
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Prometrium is used as part of hormone replacement therapy for women who underwent menopause (menopause) and did not have a hysterectomy (surgical removal of the uterus). Prometrium is also used to cause menstruation for women of childbearing age.
Clomid - anti-estrogen of nonsteroid structure which is taken for treatment of anovular infertility, dysfunctional metrorrhagia, amenorrhea, secondary amenorrheas, post-contraceptive amenorrheas, galactorrhoea (against the background of hypophysis tumor), syndrome of polycystic ovaries (sclerocystic disease of the ovary), Chiari-Frommel disease, androgenic insufficiency, oligospermatism, diagnosis of disturbances of gonadotropic function of hypophysis.
Fertomid an antiestrogenic medical remedy of a nonsteroidal structure. It is called to activate the ovulation in an infertile female due tosecond-rate ovarian hypo-function, mainly purposed by the functional hypothalamic-hypophyseal disorders. Used to cure anovulatory disorders of cycles of central hypothalamic origin, second-rate amenorrhea of different etiology, menstrual disorder. It is assigned in cases of amenorrhea after the use of contraceptives, the pathological spontaneous outflow of the breast milk not connected with a baby breastfeeding, the syndrome of Stein-Leventhal, Chiari-Frommel syndrome, and oligospermia.