Colchicine is a means that affects the metabolism of uric acid, which contains the active substance: colchicine. Colchicine tablets are used for the treatment of acute gout attacks and prevention of acute attacks of gout in the initial treatment with allopurinol drugs or drugs that contribute to the excretion of uric acid. A single initial dose of the drug is 1 mg, then-0.5 mg every 2-3 hours until pain relief. This drug is contraindicated for people during pregnancy, breastfeeding, and children.
Colchicine
| Package | pill | Total price | Save | Order |
|---|---|---|---|---|
| 0.5mg × 60 Pills | $0.55 | $33.18 + Bonus - 4 Pills | - | Add to cart |
| 0.5mg × 90 Pills | $0.48 | $42.81 + Bonus - 7 Pills | $6.30 | Add to cart |
| 0.5mg × 120 Pills | $0.44 | $52.42 + Bonus - 7 Pills | $13.20 | Add to cart |
| 0.5mg × 180 Pills | $0.40 | $71.67 + Bonus - 11 Pills | $27.00 | Add to cart |
| 0.5mg × 270 Pills | $0.37 | $100.54 + Bonus - 11 Pills | $48.60 | Add to cart |
| 0.5mg × 360 Pills | $0.36 | $129.40 + Bonus - 11 Pills | $68.40 | Add to cart |
Your order will be packed safely and securely and dispatched within 24 hours. This is exactly how your parcel will look like (pictures of a real shipping item). It has the size and the look of a regular private letter (9.4x4.3x0.3 inches or 24x11x0.7cm), and it does not disclose its contents
Product description
Colchicine is a widely prescribed medicine applied in adults when prevention and treatment of gout flares are needed.
The effects described below have been proposed as the potential mechanism of action for colchicine in gout.
1) Uric acid crystals located in the affected joint are taken up by macrophages. On this stage, Colchicine seems to intrude in the process of phagocytosis of those uric acid crystals.
2) Activated macrophages generate IL-1β by using intracellular inflammasomes. It is supposed that colchicine impairs the work of the inflammasome complex by inhibiting IL-1β activation.
3) Said IL-1β provides help with recruitment of neutrophils from the bloodstream directly into the affected joint. Colchicine potentially prevents neutrophils from migrating in the nidus of inflammation.
4) Since it is the activation and degranulation of the migrated neutrophils that contribute to acute pain associated with gout flare, colchicine is designed to successfully intervene with these processes, thus relieving the patient from constant pain.
Important! Colchicine is not a pain-killer and cannot be administered in treatments of pain caused by other conditions.
How to take
Maintain the dosing procedure your healthcare advisor provided you with. If in doubt regarding the correct dosing, contact your doctor to clarify the drug amount and appropriate schedule.
If you suspect an event of overdose, call the ambulance or go to the hospital close by.
Patients should not discontinue Colchicine even their symptoms improve significantly. Please follow your physician’s directions as closely as possible.
Your healthcare advisor may ask you to have your blood checked regularly while you are staying on Colchicine.
If your symptoms of gout flare get acute during the therapy, report this to your primary care doctor.
Safety information
This medicine can lead to serious side effects or even death if the active substance levels exceed the normal ones in your body. Co-administering certain drugs with Colchicine lead to such a disbalance, even if you stick to the recommended dose. This issue concerns sufferers of kidney or liver issues in particular.
Notify your healthcare advisor of all your current medical conditions and the pharmaceutical products you are using, including vitamins, additives and natural fresh juices.
Fatal overdoses, both intentional and accidental, have taken place in cases of adults and children taking the medicine. Ensure that colchicine remains out of the reach of unauthorized persons and children.
The drug can also become the reason of acute muscle problems and severe blood disorders even if ingested as directed. Elderly patients face a greater chance for muscle issues, as well as those taking other pharmaceutical products with Colchicine, or suffer from kidney problems.
Side effects
The most common adverse reactions in sufferers of gout flares are throat pain (3%) and diarrhea (23%).
Seek medical help immediately, if your condition is characterized by:
- Unusually easy bleeding or bruising;
- Lack of feeling or in your fingers/toes or tingling sensations;
- Muscular weakness or pain;
- Feeling of weakness or tiredness;
- Acute diarrhea and/or vomiting;
- Discoloration of the tongue, lips, or palms.
Sufferers of Gout Flares: Most commonly, those patients experience moderate diarrhea.
Sufferers of FMF: Most commonly, those patients experience stomachaches, diarrhea, nausea and/or vomiting.
The antibiotic produced by Streptomyces lincolniensis, has a bacteriostatic effect. Suppresses protein synthesis of bacteria due to reversible binding to the 50S subunit of ribosomes, disrupts the formation of peptide bonds.
It is active against gram-positive cocci Streptococcus spp., including Streptococcus pneumoniae); Haemophilus influenzae; Bacillus anthracis, Mycoplasma spp., Bacteroides spp., Corynebacterium diphtheriae, Clostridium perfringens, Clostridium tetani.
A drug for the prevention and treatment of HIV infection. An antiviral agent, which competitively blocks the reverse transcriptase and selectively inhibits the replication of viral DNA.
Accupril, which is quinapril, medication with hypotensive, natriuretic, cardio-protecting effect and vasodilating properties. It is used in case of an arterial hypertension (mono- or combined therapy), heart failure (combined therapy).
Glucotrol peroral hypoglycemic medicine. It is taken at a diabetes mellitus of type 2 (at inefficiency of dietotherapy). It has pancreatic and extra pancreatic effects. Stimulates secretion of insulin by reductions of the threshold of irritation with glucose of beta cells of pancreas, increases sensitivity to insulin and extent of its linkng with target cells, increases insulin release, strengthens influence of insulin on glucose absorption by muscles and liver, brakes lipolysis in fatty tissue.
Diflucan - antifungal medicine, possesses highly specific action, inhibiting activity of enzymes of fungus. It is taken at systemic lesions caused by fungus including meningitis, sepsis, infections of lungs and skin as at patients with a normal immune response, and at patients with various forms of immunosuppression.
Hyzaar - complex hypertensia medicine. A hydrochlorothiazide - Thiazide diuretic of average force and losartan - hypotensive drug which is specific blocker angiotensin II (AT1 type) of receptors. Does not suppress a kinase II - enzyme destroying bradykinin.
Tricor - is a hypolipidemic agent, has an uricosuric and antiplatelet effect. In combination with diet therapy, the drug is prescribed for a long-term treatment, the effectiveness of which must be periodically checked by determining serum lipid levels.
Zudena is another representative of the PDE5 inhibitors ubiquitously used in contemporary urology. It is commonly used for the therapy and prevention of erectile dysfunction. The pills contain udenafil – a reverse inhibitor of the phosphodiesterase-5, which is responsible for filling the penis with blood. This active ingredient has a range of recently introduced advantages the most notable of which are more rapid absorption (30-60 minutes) and increased half-life (starting from 10 to 12 hours, which leads to a 24-hour period of activity). The medicine may be prescribed not only for symptomatic but also for a long-term treatment.
The main effect of Top Avana lies in the sustainment of a sexually productive penile erection. Its extra benefit in males consists in a significant enlargement of the coitus and postponement of ejaculations. The drug’s component Avanafil inhibits the body chemical preventing an ED patient from getting an erection. Avanafil enzymatically enhances the circulation and lets the corpus cavernosum stay pumped with blood.
Cialis Professional - effective tablets for improvement of erection. They begin to work in 15 minutes from the moment of taking and actions for 36 hours. They can cause not less than 10, but no more than 16 erections. The medicine increases duration of sexual intercourse. The tablets are successfully used for reduction of time for recovery of erection after ejaculation.
Gastroprotective agent, a synthetic analog of PgE1 boosts the formation of defensive slime and bicarbonate; enhances blood flow in the mucosa. It stimulates the healing of erosions, gastric and duodenal ulcers and is able to prevent their formation in some cases. It has a direct impact on the parietal cells of the abdomen, inhibits the lowest, and stimulated (by meal,pentagastrin, histamine) excretion of HCl. he drug diminishes the basal production of pepsin. The expected result occurs after 30 minutes and lasts at least 3-6 hours.
stimulant of the intestinal peristalsis. Motillium is assigned in cases of: distention, overeating, vomiting, heartburn, flatulence, a feeling of overflow of the stomach.
Methocarbamol – a muscle relaxant used to treat muscle spasms and pain. Its action is to block pain nerve impulses sent to the brain. The mechanism of action is not completely clear. The drug has no direct effect on skeletal muscles. It's likely that its effect is associated with sedative properties.
Trecator SC - an anti-TB drug (antituberculous), contains Ethionamide as a basic substance, the drug is prescribed for the treatment of multidrug-resistant type of tuberculosis, with the mycobacterium tuberculosis susceptible to it.
Depakote - antiepileptic medicine, has the central myorelaxation and sedative effect. It is taken for treatment of epilepsy of various genesis, at epileptic seizures, febrile spasms at children, and character changes caused by epilepsy.
Cordarone - antiarrhytmic drug of III class (repolarization inhibitor). Possesses also anti-anginal, coronarodilator, alpha and beta, adrenoceptor blocking and hypotensive action. The anti-anginal effect of Cordarone is caused by coronarodilator and anti-adrenergic action, reduction of need of a myocardium for oxygen.
Antiepileptic agent. The use of Lamictal reduces the pathological activity of neurons without inhibiting their function. Stabilizes the neuronal membranes by affecting Na + channels, blocks excessive release of excitatory amino acids (mainly glutamate), without reducing its normal release.
Olanzapine is an antipsychotic drug (neuroleptic). It is shown in schizophrenia in adults, psychotic disorders, bipolar affective disorder in adults, depressive states.
The local application of Rogaine 2 has a stimulating effect on hair growth in men and women with androgenetic alopecia. In clinical studies, it is reported that Regain stimulates hair growth and stops it falling out in cases when it begins to fall from the top (men) or in the middle part (women). The stimulation of hair growth begins approximately 4 months after using the product. After the withdrawal of the drug, the growth of new hair stops. In patients with normal or high blood pressure, a local use of the medicine was not accompanied by common side effects.
Propecia - an anti-hormonal drug. Used to reduce the size of the prostate gland, to increase the maximum speed of urine outflow, reducing the risk of developing acute urinary retention. The drug also turned out to be effective in the treatment of men’s alopecia.
Finpecia - potent pharmaceutical agent aimed to cure an illness named alopecia, of an androgenic as well as a hereditary genesis. Moreover, it stops the manifestation of various maladies deteriorating the advancement of the follicles and other difficulties connected with baldness.
Cardizem, derivative benzothiazepine, has anti-anginal, antiarrhytmic and hypotensive effect. It is prescribed at arterial hypertension: after myocardial infarction, at patients with accompanying stenocardia when beta adrenoblockers, are contraindicative at patients with diabetic nephropathy, in cases when ACE inhibitors are contraindicated; angina of effort, Prinzmetal's angina; prevention of a coronary spasm when carrying out a coronary angiography or operation of aortocoronary shunting.
Atorlip-5 is a drug which purpose is to lower the level of so-called bad cholesterol in the human organism. Its amount is identified due to the blood testing. The accumulation of low-density lipoprotein can lead to atherosclerosis. As the result, arteries are getting narrow causing cardiovascular complications as strokes, heart attacks, hypertonia, and peripheral artery disease. Liver fat can be also reduced thanks to the drugs. The other benefit is that the medicine increases the level of high-density lipoprotein.
Uroxatral - Alfuzosinis an active substance, as an antagonist of the α1 adenogenetic receptor, this drug relaxes the muscles of the prostate and the bladder. Used in the treatment of benign prostatic hyperplasia (BPH). Reduces pressure in the urethra and reduces resistance to urine flow, eases urination and eliminates dysuria.
Hytrin refers to the group of pharmaceutical products intended to cure the sexual/urinary maladies and sex hormone medical preparations. Its composition includes Terazozin - a medical mean for the normalization of the prostate gland in benign hypertrophy.
Trileptal is used to treat simple and complex forms of partial epileptic seizures that have secondary generalization (possibly without it) beginning at the age of one month; generalized tonic-clonic forms of epileptic seizures in patients from two years of age. Reviews about Trileptal have a positive connotation, which allows to determine its effectiveness in use, thanks to patients who have experience of taking the drug.
Etodolac - has an anti-inflammatory, analgesic, antipyretic effect. The medicine is prescribed in case of rheumatoid arthritis, ankylosing spondylitis, arthrosis with pain syndrome and restriction of movements, acute and chronic osteoarthritis.
Voveran SR is the special formulation of Voveran, developed for the suspended release of its active ingredients and, consequently, a prolonged period of action. Apart from this feature, it has no notable characteristics differentiating it from the original medicine – an analgesic that provides satisfying results in the treatment of moderate pain syndromes. It helps with a wide range of painful conditions allowing patients to stop the pain before it grows stronger or control it in case of chronic joint diseases. In general, the new form provides better results in particular in the treatment of prolonged pain.
Xeloda is a cytostatic drug. The drug is used for the treatment of patients with metastatic or locally advanced breast cancer, including after an ineffective chemotherapy course, which included anthracycline drugs and taxanes, and also if the patient has contraindications to anthracyclines.
A nonsteroidal anti-inflammatory drug that has anti-inflammatory, analgesic, antipyretic action. Prescribed for inflammatory diseases of the musculoskeletal system (rheumatoid, gouty arthritis, arthritis, ankylosing spondylitis), pain syndrome (ossalgia, neuralgia, myalgia, arthralgia, sciatica, headache, dental pain, childbirth), for orthopedic surgery, cancer, algodismenorrhea, febrile syndrome.
Fosamax - drug for treatment of Paget disease, osteoporosis at women in a postmenopause, osteoporosis at men, a hypercalcemia at malignant tumors. Active alendronate ingredient - non-hormonal specific inhibitor of an osteoclastic bone resorption, suppresses osteoclasts. Taking of Fosamax stimulates bone formation, recovers positive balance between a resorption and recovery of a bone, progressively increases the mineral density of bones, promotes formation of a normal bone tissue with normal histologic structure.
Fluoxetine is an antidepressant group of selective serotonin reuptake inhibitors. It has a timoanaleptic and stimulating effect. It is used for depression of various genesis, obsessive-compulsive disorders, bulimic neuroses.